STUDY OF THE ASSOCIATION OF BLOOD MANGANESE LEVEL WITH DIABETES AND CHRONIC RENAL DISEASE IN INDUSTRIAL AREA OF RAIPUR CHATTISGARH

Dr. Swati Hiwale; Dr Brajendra Kumar

Volume : VIII, Issue : III, March - 2018

STUDY OF THE ASSOCIATION OF BLOOD MANGANESE LEVEL WITH DIABETES AND CHRONIC RENAL DISEASE IN INDUSTRIAL AREA OF RAIPUR CHATTISGARH

Dr. Swati Hiwale, Dr Brajendra Kumar

Abstract :

The purpose of this study was to evaluate the association between blood manganese levels and the prevalence of chronic diseases in the industrial area of RAIPUR,CHATTISGARH STATE The study included 400 participants 20 years of age or older whose blood manganese levels had been measured. The participants were also evaluated for the presence of five chronic diseases: diabetes, renal dysfunction, hypertension, ischemic heart disease, and stroke.Blood manganese levels were significantly lower in the diabetes group compared with the non–diabetes group (1.26 ± 0.02 vs. 1.35 ± 0.01 μg/dL; p = 0.001) and the renal dysfunction group compared with those with normal renal function (1.28 ± 0.03 vs. 1.35 ± 0.01 μg/dL; p = 0.04). There was no significant association between blood manganese levels and the presence of ischemic heart disease or stroke. A multivariate logistic regression analysis adjusted for age, sex, and body mass index was performed; the odds ratio was 0.652 (95% CI: 0.46–0.92) for diabetes and 0.589 (95% CI: 0.39–0.88) for renal dysfunction when compå the higher quartiles (Q2–4) with the lowest quartile (Q1) of blood manganese level. The prevalence of diabetes was 7.6% in Q1 and 5.3% in Q2–4 (p = 0.02). Similarly, the prevalence of renal dysfunction was 6.8% in Q1, compared with 4.6% in Q2–4 (p = 0.02).The prevalence of diabetes and renal dysfunction increased in participants with low blood manganese levels, suggesting that blood manganese may play a role in glucose homeostasis and renal function.