STUDY ON ANTIBIOTIC PROFILE OF MDR PSEUDOMONAS AERUGINOSA (MDRPA) ISOLATES FROM BURN PATIENTS: TIP OFF TREATMENT OF CHOICE.

Sabetha T; Nithyalakshmi J; Nirupa S; Vidhyarani R

Volume : VII, Issue : X, October - 2017

STUDY ON ANTIBIOTIC PROFILE OF MDR PSEUDOMONAS AERUGINOSA (MDRPA) ISOLATES FROM BURN PATIENTS: TIP OFF TREATMENT OF CHOICE.

Sabetha T, Nithyalakshmi J, Nirupa S, Vidhyarani R

Abstract :

Burn wards harbour MDR pseudomonas aeruginosa which subsequently colonize burn wounds leading to life threatening infection. MDRPA strains pose a challenge in selecting the most appropriate antibiotics worldwide. This study was undertaken to identify the isolation rate of MDR Pseudomonas aeruginosa and its antibiotic profile among the burns patients. Materials and Methods: This study was conducted over a period of 6 months in a burn unit of Government medical college Hospital and Research Institute, Chennai. 267 consecutive clinical samples from burn unit were collected during this period. The isolates were identified and antibiotic sensitivity testing of all P.aeruginosa isolates was done using Kirby–Bauer disc diffusion method and the results were interpreted according to the CLSI guidelines. Ceftazidime resistant strains were subjected to MIC by agar dilution method. Results: Out of 267 clinical samples, 108 P. aeruginosa was isolated. Among them, 35.18% was found to be MDRPA. 55% were resistant to beta–lactams – piperacillin, 26% were resistant to piperacillin–tazobactam, 19% were resistant to ciprofloxacin and 2.36% were resistant to carbapenems. All isolates were resistant to ceftazidime (100%).MIC of Ceftazidime revealed majority of the strains had eakpoints at 64μg/ml. Conclusion: Periodic review of antibiotic profile of MDRPA in burn patients should be the leading priorities to curtail the menace of resistance. < clear="all" style="page–eak–before:always; mso–eak–type:section–eak" />