Volume : V, Issue : V, May - 2015

Study on some Bacteriological and Immunological aspects of Septicemia in Neonate in Baghdad

Rajwa H. Essa, Waseem F. Mohammed, Rabab Q. Al Segar, Nadheema H. Hussein, Khetam H. Rasool

Abstract :

One hundred blood specimens were collected from neonatal patients below twenty eight days whom suspected to have septicemia in Baghdad pediatric hospitals. The results have revealed that 34(34 %) gave positive blood culture whereas 66 (66 %) gave no growth. among 34 positive blood culture cases 21 (61.76%) were males and 13 (38.24%) were females. Among 34 positive blood culture cases 24 (70.59%) belonged to lateonset neonatal sepsis (LONS) and 10 (29.41%) belonged to early onset neonatal sepsis (EONS). So the incidence was higher in LONS than EONS.Among 34positive blood culture cases twenty (58.82%) were of low birth weight (LBW) and fourteen (41.18%) were of normal birth weight (NBW) so the incidence of neonatal septicemia was higher in LBW neonates compared to NBW. NNS were 22 cases (64.70%) preterm and 12 (35.30%) were term. The incidence of preterm neonates was higher compared with term neonates.Gram–positive bacteria were (52.94%) which higher than Gram–negative bacteria (47.06%). Burkholderiacepacia is isolated from neonatal sepsis(NNS) for the first time in Baghdad accordingly to our information subject.Antibiotic sensitivity test was detected by using Kirby–Bauer methodandVancomycin was the most effective antibiotics on gram–positive bacteria while imipenem and amikacin were the most effective antibiotics on gram–negative bacteria.The immunological aspect was done by determination of the concentration of immunoglobulines (IgA, IgG and IgM) and some complement components (C3 and C4) in neonates(12 of NNS and 12 control neonates) serum.The mean of concentrations of preterm control neonate IgA 20.3 mg/dl, IgG512.5 mg/dl, IgM 16.6 mg/dl, C3 77.7 mg/dl and C4 17.7 mg/dl were lower than mean of concentrations of term control neonate IgA 23.6 mg/dl, IgG851.1 mg/dl, IgM 18.9 mg/dl, C3 126.5 mg/dl and C4 24.6 mg/dl, the mean of concentrations of preterm NNSIgG350.5 mg/dl, C3 56.6 mg/dl and C4 13.6 mg/dl were significant (P<0.05) lower than mean of concentrations of preterm control neonate IgG512.5 mg/dl, C3 77.7 mg/dl and C4 17.7 mg/dl and IgM 28.9 mg/dl of preterm NNSwas significant (P<0.05) higher than mean of concentrations of preterm control neonate IgM 16.6 mg/dl while non significant of IgA and we showed that the mean of concentrations of term NNSIgG492.5 mg/dl, C3 67.4 mg/dl and C4 16.7 mg/dl were significant (P<0.05) lower than mean of concentrations of term control neonate IgG851.1 mg/dl, C3 126.5 mg/dl and C4 24.6 mg/dl and IgM 34.8 mg/dl of term NNSwas significant (P<0.05) higher than mean of concentrations of term control neonate IgM 18.9 mg/dl while non significant of IgA, thus the relative risk of acquiring sepsis in neonates was greater with IgG 350.5 ± 76.7 mg/dl  

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Rajwa H. Essa,Waseem F. Mohammed,Rabab Q.Al-Segar,Nadheema H. Hussein, khetam H. Rasool Study on some Bacteriological and Immunological aspects of Septicemia in Neonate in Baghdad Indian Journal of Applied Research, Vol.5, Issue : 5 May 2015

Number of Downloads : 559

References :