Volume : VII, Issue : I, January - 2017

STUDY ON VITAMIN D LEVELS IN CHRONIC KIDNEY DISEASE PATIENTS.

Dr . Chada Ramesh, Dr. B. Thrilok Chander, Dr . Malleshwar Bottu

Abstract :

 BACKGROUND: 1, 25–dihydroxyvitamin D [1, 25(OH) ₂ D] is the major steroid hormone   involved in mineral ion homeostasis regulation. According to various studies published, there is widespread prevalence of varying degrees (50– 90%) of Vitamin D deficiency with low dietary calcium intake in Indian population.

AIM & OBJECTIVE OF STUDY: The aim of the study is to estimate the prevalence of vitamin D deficiency in patients with Chronic Kidney disease (e–GFR <60ml/min).

STUDY DESIGN: Cross sectional observational study.

MATERIALS AND METHODS:   Patients attending the outpatient department or admitted to Nephrology ward of Gandhi Hospital in the period between Jan 2015 and Dec 2015 were examined by history, physical examination and the relevant baseline investigations were done.  Fifty patients found eligible were enrolled into the study. Chronic Kidney Disease was diagnosed by KDIGO (2012) criteria.¹ In order to eliminate the effect of differences in dietary habits or socioeconomic strata, subjects to the control group were drawn from within the CKD patient family and friends. An informed consent is taken from both cases and controls.

STATISTICAL ANALYSIS: Data analysed using the Statistical Package for Social Science (SPSS) software version19.Student T test is applied for comparisons of vitamin D and calcium levels in cases and controls.

     ANOVA  test is applied for comparison variable among three CKD cohorts. A P value of < 0.05 is taken as significant.

 

RESULTS:

Average vitamin D levels among CKD subjects is 15.74 + 7.7ng/ml.Average serum calcium level among CKD patients is 8.74( + 0.77)mg/dl where as in control it  is 8.97( + 0.51)mg/dl .In CKD patients  serum Phosphorus level and serum Alkaline Phosphatase are 4.8 ( + 1.30) mg/dl and 191.52 (+72.81)mg/dl respectively.

Average   i PTH levels in CKD patients is   230.07 (+ 138.6) pg/ml, which is above normal range.

CONCLUSIONS:

Prevalence of vitamin D deficiency significantly increases as CKD progress. Vitamin D deficiency  more prevalent among CKD patients with Diabetes. There is inverse relation between vitamin D and iPTH levels in CKD population

 

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr .CHADA RAMESH, Dr. B.THRILOK CHANDER, Dr .MALLESHWAR BOTTU, STUDY ON VITAMIN D LEVELS IN CHRONIC KIDNEY DISEASE PATIENTS., Indian Journal of Applied Research,Volume : 7 | Issue : 1 | JANUARY 2017

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