STUDY THE EFFICACY OF GAMMA & DELTA TOCOTRIENOL (50%) IN ORAL SUBMUCOUS FIBROSIS (OSMF): AN ORAL PREMALIGNANT CONDITION

Arun K Aggarwal; Harmeet Singh; Anshika Rana

Volume : IX, Issue : IX, September - 2019

STUDY THE EFFICACY OF GAMMA & DELTA TOCOTRIENOL (50%) IN ORAL SUBMUCOUS FIBROSIS (OSMF): AN ORAL PREMALIGNANT CONDITION

Arun K Aggarwal, Harmeet Singh, Anshika Rana

Abstract :

Introduction & Objective: An oral premalignant condition that is oral submucous fiosis (OSMF) which is categorized by inflammation and progressive fiosis with malignant rate due to submucosal tissues resulting in marked rigidity and trismus. The present study objective was to evaluate the efficacy of an isoprenoid compounds in the form of gamma and delta tocotrienol (50%) by comparative with conventional treatment in OSMF. Material and Method: This study was carried out in the groups confirmed OSMF which further divided into two sub–groups; each group has 15 patients elected from Aadhar Hospital, Hisar, India. The group X patients were given conventional treatment whereas group Y patients were given gamma and delta tocotrienol (50%) 400mg soft gel capsules, b.i.d orally) with conventional treatment for a period of six months. Results: The obtained results were confirmed histopathologically and showed that combination of gamma and delta tocotrienol (50%) capsules significantly improved the patient’s conditions in terms of burning sensation, pigmentation, extent of mouth opening and its effectiveness in the OSMF treatment as compared to conventional treatment alone. Conclusion: The present study overall results concluded that gamma and delta tocotrienol (50%) with conventional treatment is a safe and reliable method which played a significant role in the treatment of OSMF.