Volume : IX, Issue : VIII, August - 2019

Sulforaphane reduced genotoxicity of Aflatoxin B1 in Human lymphocyte Culture.

Md. Sultan Ahmad, Afsar Ali

Abstract :

This work was carried out to study the antigenotoxicity of sulforaphane against Aflatoxin B1, using five four concentrations viz; 40, 50, 60, and 80 μg /ml in the study. The data were collected at three durations of 24, 48, and 72 h for in vitro experiments. It was found that Sulforaphane significantly reduced chromosomal aberrations from 29.49, 52.47 and 68.65% at 24, 48, and 72h produced by Aflatoxin B1 to 14.32, 28.00 and 41.88% level, similarly sister chromatid exchanges get reduced from 16.76 ± 1.50(SE) to 8.64 ± 0.75(SE) at 48 h of treatment and replication index was enhanced from 1.27 to 1.54 in vitro. In this study we have noticed the chromosomal aberrations (CAs), sister chromatid exchanges (SCEs) were reduced and replication index was enhanced in human lymphocyte cultures. The trend of reduction was dose–dependent.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

SULFORAPHANE REDUCED GENOTOXICITY OF AFLATOXIN B1 IN HUMAN LYMPHOCYTE CULTURE., Md. Sultan Ahmad, Afsar Ali INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-8 | August-2019


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