Symptoms& Genetic Overlap in Schizophrenia and Bipolar Disorder : a selective clinical review

Amresh Shrivastava; Avinash De Sousa; Nilesh Shah

Volume : III, Issue : VII, July - 2014

Symptoms& Genetic Overlap in Schizophrenia and Bipolar Disorder : a selective clinical review

Amresh Shrivastava, Avinash De Sousa, Nilesh Shah

Abstract :

Following the recent progress mainly in the fields of genetics and neurobiology, the validity of the diagnostic distinction between schizophrenia and bipolar disorder is increasingly challenged.Evidence for basic neurobiological processes common for both disorders is expanding with regard to (a) susceptibility genes, (b) neurodevelopment (for example myelination), and (c) ain functions (for example sensory gating, visuospatial achievement). Recent epidemiological studies also stress communalities.The diagnostic split between schizophrenia and bipolar disorder is unable to define distinct etiological and/or pathophysiological entities. There is considerable ovesrlap in mood and affective features in both disorders with family histories reflecting that both disorders may run concomitantly in families. It is interesting to explore genetic and symptomatic overlap in schizophrenia and bipolar disorder from a clinical point of view to further deepen and unite the nosology of these disorders