Synergistic Activity of Antibiotics and Trachyspermum ammi (Ajwain) Extract on MDR Staphylococcus aureus

Vijay N. Charde; Pratik M. Bezalwar; Ashok V. Gomashe

Volume : IV, Issue : XI, November - 2014

Synergistic Activity of Antibiotics and Trachyspermum ammi (Ajwain) Extract on MDR Staphylococcus aureus

Vijay N. Charde, Pratik M. Bezalwar, Ashok V. Gomashe

Abstract :

New emerging trends in multidrug resistance among several groups of microorganisms against different classes of antibiotics led to development of different strategies. Total 106 Clinical samples were screened for isolation of Staphylococcus sp. Total 21 suspected isolates of Staphylococcus aureus were identified on the basis of morphological, cultural & biochemical characteristics and all of them were found to be Staphylococcus aureus. 17 isolates were associated with pus samples, 3 with urinary tract infection (UTI) and 1 was associated with blood. Antibiogram study of these isolates revealed that all these isolates are resistant to several antibiotics out of 16 antibiotics tested. Synergistic study of extracts of T. ammi and antibiotics on susceptibility of resistant Staphylococcus isolates showed that most of the extracts exhibited potentiating effect on antibiotics. The potency shown by these extracts may explore their use against multidrug resistant microorganisms in combination therapy