Volume : IV, Issue : I, January - 2014

Synthesis and Antimicrobial Activity of some Trisubstituted Thioxoimidazolidinones

Mohamed Abd El Latif Zein, Elsayed M. Abd El Rahim

Abstract :

3-(Substituted) amino-2-thioxoimidazolidinones (3a, b) were prepared via condensation of 1-substitued thiosemicarbazones (2a, b) with ethyl chloroacetate in presence of fused sodium acetate. Reaction of (3a,b) with acetic anhydride, ethyl acetate in presence of sodium metal in Xylene and aromatic aldehydes in presence of piperidine yielded the corresponding 1-acetyl-3-(substituted)amino-2-thioxoimidazolidinones(4a,b),5-acetyl-3-(substituted)amino-2-thioxoimidazolidinones (5a,b) and 5-arylidene-3-(substituted) amino-2-thioxoimidazolidinones (6a,b). Reaction of (4a,b) with aromatic aldehydes in presence of piperidine and/or acetylation of (6a,b) by acetic anhydride yielded 1-acetyl-5-arylidene-3-(substituted) amino-2-thioxoimidazolidinones (7a,b). Bromination of (3a,b) with omine gave the corresponding 5-omo-3-(substituted)amino-2-thioxoimidazolidin-2-one (8a,b). Some of the synthesized compounds also exhibited antimicrobial activities.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Mohamed Abd El-Latif Zein, Elsayed M. Abd El-rahim Synthesis and Antimicrobial Activity of some Trisubstituted Thioxoimidazolidinones Indian Journal of Applied Research, Vol.IV, Issue. I

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