Synthesis, characterization and antimicrobial studies  of (morpholine–4–yl–pyridin–2–yl–methyl)–urea and its  metal (II) complexes

M. Syed Ali Padusha; T. Chandrasekaran and M. Suresh

Volume : III, Issue : XII, December - 2013

Synthesis, characterization and antimicrobial studies of (morpholine–4–yl–pyridin–2–yl–methyl)–urea and its metal (II) complexes

M. Syed Ali Padusha, T. Chandrasekaran And M. Suresh

Abstract :

Morpholine, pyridine–2–carbaldehyde and urea reacted yielding a new N–terminal Mannich base, (morpholine–4–yl–pyridin–2–yl–methyl)–urea (MPU). Cobalt (II), Nickel (II) and Copper (II) complexes of MPU were synthesized. The structure of MPU was established by analytical methods such as elemental analysis, melting point, TLC and spectral methods such as IR, 1H NMR, 13C NMR and Mass spectral studies. The elemental analysis, molar conductance, magnetic susceptibility study, UV–vis, IR, 1H NMR, 13C NMR and ESR studies were carried out to establish the structure of the complexes. The antimicrobial activity of the ligand and its complexes was extensively studied by disc diffusion method. The results of antimicrobial studies of the compounds revealed that they possess inferior potency when compared to the standard employed.