Volume : IV, Issue : XI, November - 2014

Synthesis, Characterization and Biological screening of some new Bis–1,4–dihydropyrimidines

Varsha Samdhian, Monika Bansal, Swaranjit Singh Cameotra, Balbir Kaur

Abstract :

Bis–1,4–dihyropyrimidines (5a–k, 6a–k) were synthesized by S–alkylation of tetrahydropyrimidines using 1,4–diomobutane and 1,5–diomopentane. All the synthesized compounds were characterized using elemental analytical (C, H and N) and spectral (FT–IR, 1H–NMR, 13C–NMR and MS) data. Some of the titled compounds evaluated for in vitro antibacterial activity against Bordetella onchiseptica (MTCC 6837) and also screened for their antioxidant activity. The tested compounds exhibited potent antibacterial activity against Bordetella onchiseptica (gram negative bacteria) and it was found that synthesized compounds are better antibacterial agents and mild antioxidants.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Varsha Samdhian, Monika Bansal, Swaranjit Singh Cameotra, Balbir Kaur Synthesis, Characterization and Biological screening of some new Bis-1,4-dihydropyrimidines Indian Journal of Applied Research, Vol.4, Issue : 11 November 2014

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