Synthesis, Characterization and DNA cleavage studies of Mononuclear Cobalt (II) complex derived Isatin and Aniline

Sathya Babu; Akila Ekamparam

Volume : VII, Issue : VIII, August - 2017

Synthesis, Characterization and DNA cleavage studies of Mononuclear Cobalt (II) complex derived Isatin and Aniline

Sathya Babu, Akila Ekamparam

Abstract :

The mononuclear Schiff base and its cobalt (II) complex is derived by the condensation of isatin and aniline. The cobalt chloride is added to this ligand in the ratio 1:2 to form mononuclear cobalt complex [ML₂X₂] where M = metal, L = Schiff base ligand, X = chloride ions. The characterization such as elemental analysis, molar conductance, and magnetic moment, IR, UV and H¹ NMR for ligand and its complexes have been studied. The spectral data shows that it is in distorted octahedral geometry. The pUC18 DNA cleavage study was monitored by agarose gel electrophoresis method. From this study it was found that the mononuclear Co(II) complex cleaves pUC18 DNA in the presence of the oxidant H₂O₂. From the antibacterial activity the cobalt(II) complex shows higher activity than the ligand.