SYSTEMATIC EVALUATION OF ETHANOLIC LEAF EXTRACT OF CARYOTA URENS ON NERVOUS DISORDERS IN ANIMAL MODELS

Ragul B; Loknath B; Jaikumar S

Volume : IX, Issue : V, May - 2019

SYSTEMATIC EVALUATION OF ETHANOLIC LEAF EXTRACT OF CARYOTA URENS ON NERVOUS DISORDERS IN ANIMAL MODELS

Ragul B, Loknath B, Jaikumar S

Abstract :

Central nervous system plays a vital role in the physiological organization of the completely human body. In modern world, everyday people suffered by depression, anxiety, epilepsy and restlessness due to stress. According to WHO report, about 450 million people suffer from a mental or behavioral disorder. While, majority of modern drugs synthetic agents causes side effects on like tiredness, weight gain, nausea, dry mouth, sexual dysfunction, amnesia, sedation, headache and wooziness. The affinity towards the herbal drugs has been grown by utilization of traditional medicinal plant due to its safety and better alternative to synthetic drugs that assure numerous side effects during prolonged treatment. Use of herbal medicine has been increased due to its safety and plays vital role in CNS disorders. The urens is the principle phytoconstituent present in the Caryota urens, and others are flavonoids, phenolic compounds, amino acids, alkaloids, proteins and carbohydrate which are medicinally important and responsible for treating various illness including neurological disorders. The study was conducted with an aim, to assess the influence of Caryota urens leaf extract on CNS by evaluating its effect on various neurological disorders in experimental animal models. The CNS activities of dried ethanolic leaf extract of Caryota urens (200 and 400mg/kg) were evaluated using various models for antidepressant activity, anxiolytic activity, locomotor activity and muscle relaxant activity. The ethanolic leaf extract Caryota urens (ELECU) dose dependently increase the number of head dips, which indicate, that the leaves of Caryota urens shows antidepressant activity. ELECU significantly increases both the number of entries and time spent in open arm. Both the doses of ELECU showed mild to moderate decrease in locomotor activity in dose dependent manner. The present study showed a dose–dependent increase in muscle relaxation with both the doses of ELECU. All the CNS mediated effects of ELECU were similar as that of diazepam the standard drug. It is concluded that the ethanolic leaf extract of Caryota urens possess significant CNS effect on various animal models. However, further studies are necessary to examine the underlying mechanisms of CNS effects and to isolate the active compounds responsible for its activity.