Testicular toxicity of cypermethrin in adult and young male rats

Laila A. Hummdi; El–sayda H. Abdelaziz; Aisha D. Alalwani; Enaya A. Abualnasor

Volume : VI, Issue : I, January - 2016

Testicular toxicity of cypermethrin in adult and young male rats

Laila A. Hummdi, El Ndash Sayda H. Abdelaziz, Aisha D. Alalwani, Enaya A. Abualnasor

Abstract :

Pesticides are widespread synthesized substances used for public health protection and agricultural programs. However, they cause environmental pollution and health hazards. This study aimed to investigate the sub–acute effect of Cypermethrin (CYP) and to evaluate its effects of on the testis histology in adult and young male Wistar rats. To investigate the acute oral toxicity dose of CYP, adult and young rats were subdivided into 11 groups with ten animals each. Ten graduated doses were given orally to 10 groups of rats for the determination of LD50. The acute oral LD50 value was calculated as 344.45 mg/kg. BW for adult rats and as 204.61 mg/kg. BW for young rats. Histological alterations induced in eby CYP insecticide exposure were investigated in adult and young rats by administration of low dose equal to 1/60 of LD50 and a high dose equal to 1 / 20 of LD50 for different periods 14, 28,42 days. Our results showed that many changes in testes. Testicular structure abnormalities included atrophic and distorted seminiferous tubules, deformed and disordered arrangement of germ cells, reduced germ cells, Sertoli cells and Leydig cells, vacuolization and multinucleated formations of spermatids in the CYP–treated rats. These results suggested that CYP induces impairments of the seminiferous tubules structure and spermatogenesis in the rats and therefore damages of the male reproductive system.