THE ANTI HYPERLIDEMIC AND HYPOGLYCEMIC EFFECT OF SIDDHA FORMULATION KARUVEPILLAI CHOORANAM IN EXPERIMENTAL DIABETES AND THEIR EFFECTS ON METABOLIC ENZYMES INVOLVED IN CARBOHYDRATE METABOLISM

Manoharan A; Chittibabu CV

Volume : IX, Issue : V, May - 2019

THE ANTI HYPERLIDEMIC AND HYPOGLYCEMIC EFFECT OF SIDDHA FORMULATION KARUVEPILLAI CHOORANAM IN EXPERIMENTAL DIABETES AND THEIR EFFECTS ON METABOLIC ENZYMES INVOLVED IN CARBOHYDRATE METABOLISM

Manoharan A, Chittibabu Cv

Abstract :

Background: Diabetes mellitus is a metabolic disorder which is financial burden on national health care systems. During this condition body does not produce or properly utilize insulin and leading to disturbance in carbohydrates, proteins and lipids metabolisms and in later leads to complications such as CAD, Retinopathy, Neuropathy and Nephropathy. In 2014, the IDF estimated that 8.2% of aged 20–79 (387 million people) were living with diabetes and obesity. In 2018 2–2.5 million people are affected anobesity, out of which a whooping 40–60% have diabetesmelitus (Diabesity),nearly 80% of indian type2 diabetic patients are nonobese,where as 60–80% of such diabetics in the West are Obese (Das 1994,Sahay BK 1993). Objective: The present study is to investigate ,the effective role of Karuvepillaichooranam on changes in Body weight, Plasma glucose, Haemoglobin ,glycosylated haemoglobin and lipid profile. Materials and methods: Streptozotocin induced Wistermale albino rats weighing between 180–220gms are used in this study. The rats were divided into 5 groupseach grouphave6 rats, totaly30 albino rats used. The Karuvepillaichooranam (KVC) 100 and 200 mg/kg dividing dosewere administered orally for 28 days. The end of study showed , body weight, blood glucose, haemoglobin, glycosylated haemoglobin, plasma insulin, total cholesterol, triglycerides, HDL–cholesterol and phospholipids and glycogen content and antioxidant enzymes level were determined. Result ;The significant increase in the plasma insulin level and reduced glycosylated haemoglobin, thereby kvc is reduced hyperglycaemia and body weight, increasing the level of total haemoglobin in diabetic rats and protect massive body weight loss seems to be due to its ability to reduce hyperglycaemia. The levels of Lipid profiles are decreased and HDL–cholesterol was increased. Significantly increased in hexokinase, Glucokinase activity and glucose–6–phosphate level.