THE ANTIPSYCHOTIC ACTIVITY OF AQUEOUS EXTRACT OF WITHANIA COAGULANS FRUITS IN SWISS ALBINO MICE

Volume : VIII, Issue : VI, June - 2018

Dr. Amit S. Kamdi, Dr. Sarika Kokane, Dr. Devesh D Gosavi, Suraj S. Kunchamwar, Suvarna Kalambe

Background: Schizophrenia is one of the most devastating ain disorders. It is characterized by positive, negative and

cognitive symptoms. The various antipsychotic drugs used today are not devoid of side effects. The Withania coagulans –

a vulnerable species, is not studied much for its central nervous system effects except in late seventies. Therefore, it was thought worthwhile to

investigate anti–psychotic activities of aqueous extract of Withania coagulans fruits.

Methods: Haloperidol induced catalepsy and Cook’s Pole Climb Apparatus for conditioned avoidance response were used for testing the

antipsychotic activity.

Results: There was statistically (p–value >0.05) no significant association between aqueous extract of Withania coagulans fruits with

antipsychotic activity in Swiss albino mice.

Conclusion: Aqueous extract of Withania coagulans fruits did not demonstrate antipsychotic activity in Swiss albino mice.