THE ASSOCIATION OF HELICOBACTER PYLORI IN THE VARIOUS DISEASES DETECTED THROUGH ENDOSCOPY � STUDY AT A TERTIARY CARE CENTER

DR.ROY ALBAN FRANK; DR.RESHMINA DSOUZA

Volume : V, Issue : XI, November - 2015

THE ASSOCIATION OF HELICOBACTER PYLORI IN THE VARIOUS DISEASES DETECTED THROUGH ENDOSCOPY � STUDY AT A TERTIARY CARE CENTER

Dr. Roy Alban Frank, Dr. Reshmina Dsouza

Abstract :

 Acid peptic disease comprises of a wide spectrum of diseases, which cause considerable morbidity. Abdominal discomfort is the most common symptom. It is felt anywhere between the navel and the eastbone, this discomfort usually is a dull aching or burning pain, occurring when the stomach is empty, between meals or during the night. The abdominal discomfort may be iefly relieved by eating food or by taking medications. It may last for minutes to hours. The other symptoms include weight loss, poor appetite, bloating, nausea and vomiting. Infection with H. Pylori is considered to be an important factor in causing gastritis in general population. duodenal ulcer has a higher association with H.Pylori than gastric ulcer.To study the prevalence of Helicobacter pylori in patients with duodenal ulcer. The patients with dyspepsia who were subjected for upper gastro–intestinal endoscopy were evaluated with the biopsy specimens, one of the antral area and the pathological area, were immediately inoculated into the freshly prepared urea oth, containing phenol red as the indicator. The data collected was analyzed statistically100 cases of dyspepsia, studied clinically as per the proforma over a period of two years from July 2010 to June 2012. They were subjected for upper gastro–intestinal endoscopy under topical anesthesia, during which, 4 biopsies two each from the antrum and the pathological area were taken. Two biopsy specimens, one of the antral area and the pathological area, were immediately inoculated into the freshly prepared urea oth, containing phenol red as the indicator. Positive test for Helicobacter pylori was indicated by the change in the colour of the medium from yellow to pink or red. The other two biopsy specimen were sent for routine histopathology and special staining with Giemsa stain. The case was taken as Helicobacter pylori positive, when the histopathological examination was positive. RESULTS: Of the 773 cases of dyspepsia, we had 210 cases of non ulcer dyspepsia , 365 cases of gastritis,46 cases of gastric malignancy, 6 cases oesophageal cancer, 2 cases of oesophageal web, 39 cases of oesophagitis and 105 cases of duodenal ulcer. 365 cases of gastritis 126 had positivity for Helicobacter pylori and 105 cases of duodenal ulcer 98 had positivity for Helicobacter pylori.all the 225 cases which were positive by rapid urease test were also positive for H.Pylori histologically. CONCLUSION: There is a higher incidence for Helicobacter pylori in duodenal ulcer 98 than in gastritis which is statistically significant <0.001.