Volume : IX, Issue : II, February - 2019

The diagnostic accuracy of ROMA index in ovarian cancers

Dr. P. R. Vanaja, Dr. U. Sarada

Abstract :

Ovarian cancer is third most common cancer of the female reproductive system occurring 5–8 per 1,00,000 population in different parts of India. About 70% of cases of ovarian cancer are not diagnosed before reaching the advanced stages, and 5 year survival rate is associated with ovarian cancer is less than 30%. Early diagnosis is a major factor in improving the survival rate. Tumor markers serve as tools in the diagnosis of the disease. The aim of the present study was to determine the diagnostic value of sera levels of carbohydrate antigen–125 (CA–125), human epididymis protein 4 (HE4) as well as the area under the curve of the receiver operating characteristic (ROC) and the risk of ovarian malignancy algorithm (ROMA) index in ovarian cancer. The sera were measured using an electrochemilumi– nescence immunoassay on 158 individuals (64 patients with ovarian cancer, 64 with ovarian benign tumor and 30 healthy individuals) between September 2017 and May 2018. The results showed that levels of HE4 and CA–125 in the sera of the ovarian benign tumor group as well as their ROMA index were significantly higher (P<0.05) than those of the ovarian benign tumor and control groups, regardless of pre– or postmenopausal status. However, the level of CA–125 was significantly higher (P<0.05) in the ovarian benign tumor group compared with the healthy group, while the level of HE4 was similar in the two groups. The sensitivity of the ROMA index was higher (P<0.01) with detection of HE4 and CA–125. In the ovarian cancer group, the areas under ROC curves of ROMA, HE4 and CA–125 were 0.994, 0.990 and 0.941, respectively. The specificity and positive predictive value of HE4 in the premenopausal ovarian cancer group reached 98.36 and 95%, respectively. In conclusion, the results showed that the serum level of HE4 and the ROMA index are important indicators in the diagnosis of ovarian cancer. However, in addition to HE4 and CA–125 detection, the ROMA index is extremely valuable in improving the diagnostic efficiency of ovarian cancer

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

THE DIAGNOSTIC ACCURACY OF ROMA INDEX IN OVARIAN CANCERS, Dr.P.R.VANAJA, Dr.U.SARADA INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-2 | February-2019

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