The Disturbances Of Protein C Among Cardiac Valve Replacement Patients Undergoing Cardiopulmonary Bypass

Ahmed Siddig Akasha; Abdelrahman  Tambal; Sana Altahir; Fathelrahman Mahdi

Volume : IV, Issue : V, May - 2014

The Disturbances Of Protein C Among Cardiac Valve Replacement Patients Undergoing Cardiopulmonary Bypass

Ahmed Siddig Akasha, Abdelrahman Tambal, Sana Altahir , Fathelrahman Mahdi

Abstract :

Background: Protein C deficiency, either congenital or acquired, may lead to serious thrombotic events such as thrombophlebitis, deep vein thrombosis, or pulmonary embolism. This study was conducted to investigate the disturbances of protein C among cardiac valve replacement patients undergoing cardiopulmonary bypass. Objectives: To determine the disturbances of protein C in Sudanese patients among Mechanical valve replacement under going cardiopulmonary bypass. Design: Descriptive Cross sectional study Methodology: A prosthetic valve was implanted in 150 patients between August 2013 to March 2014.The age of patients ranged between 20 to 80 years with mean of 41years. Protein C was measured by ELISA method. One hundred and fifty patients underwent valve replacement: 60 patients (40%) had isolated mitral valve replacement (MVR), 46 patients (30.7%) had isolated aortic valve replacement (AVR), 26(17.3%) had duple valve replacement (DVR) and 18(12%) had coronary artery bypass graft (CABG), and 50 healthy individuals were recruited as control group. Results: Protein C was decreased significantly after cardiopulmonary bypass. Protein C was decreased in about 78.7% of the cases(118patients) and the mean was( 59.8±21.1%) versus the control the mean(111.3±26.1%) and there was significant variation (p.value ? 0.05) between the patients and controls. About 43 cases(28.7%) had decreased protein C level under 50% postoperative. These results suggest a disturbance of protein C system by extracorporeal circulation. Protein C was decreased significantly after cardiopulmonary bypass and this finding is considered to reflect the activation and consumption of the protein C system in response to generated thrombin. Conclusions: These results suggest a disturbance of the protein C system by extra corporeal circulation. Protein C was decreased significantly after cardiopulmonary bypass and this finding is considered to reflect the activation and consumption of the protein C system in response to generated thrombin.