The Dynamic of Methemoglobinemia Induced by Sodium Nitrite and its Reduction after Methylene Blue Administration in Sheep

Mario Darius Codreanu

Volume : IV, Issue : IX, September - 2014

The Dynamic of Methemoglobinemia Induced by Sodium Nitrite and its Reduction after Methylene Blue Administration in Sheep

Mario Darius Codreanu

Abstract :

The aim of the study was to determinate the speed of methemoglobin formation after administering of sodium nitrite in sheep, on intervals starting with the moment prior the administration, and 15, 30, 45, 60, 75, 90, 105 and 120 minutes after ingesting the toxic substance. Also, the speed of methemoglobin reduction was studied, after intravenous injection of methylene blue – as an antidote. In the first 60 minutes after ingestion of the toxic substance was registered a significantly increasing of speed Met–Hb formation (when the average of the methemoglobin levels reach a peak of 21.95 mg/kg), followed by a decreasing (also significant) of the average value of 6.62 mg/kg, after 120 minutes. After methylene blue administration, as antidote (8–9 mg/kg, repeated at every 6–8 hours), in sodium nitrate poisoning in sheep, we have observed an obvious decreasing of the methemoglobin values even after 5 minutes.