Volume : VII, Issue : V, May - 2017

THE EFFECT OF ANTITUBERCULAR TREATMENT ON LIVER IN FRESHLY DIAGNOSED PULMONARY TUBERCULOSIS PATIENTS RECEIVING DOTS THERAPY

Dr. K. B. Yadavendra Reddy, P. Mohini, S. Iqbal

Abstract :

 OBJECTIVES:To study the incidence and factors involved in development of hepatic damage and overt hepatitis in patients receiving antitubercular treatment as per RNTCP (DOTS therapy–intermittent regimen)                                          Methods:In this prospective study, 100 freshly diagnosed pulmonary tuberculosis patients (67 males and 33 females) attending the Medical Clinic and DOTS Center were taken up for study and were given DOTS therapy as per RNTCP guidelines (cat I or III).                                                                                                   Results:The study group of 100 pulmonary tuberculosis patients consisted of 67 males and 33 females. Age varied from 15 – 80 years. Twenty eight patients (28%) developed antituberculosis treatment induced liver damage which included 23 (23%) patients who had asymptomatic elevation of liver enzymes and 5 (5%) patients who developed overt drug induced hepatotoxicity. 50% of cases in the age group of 51–60 years and 50% of cases in the age group of > 60 years developed drug induced liver damage.                                                                                                                                                                                                                Conclusion:The incidence of asymptomatic elevation of liver enzymes secondary to antituberculosis treatment is 23% and incidence of overt DIH is 5%.  Advanced age, high alcohol intake, BMI < 18, radiologically severe disease and pretreatment hypoalbuminemia are predisposing factors for the development of ATT induced hepatotoxicity while  sex is not factor. Peak incidence of hepatitis occurs in the first month of therapy. 

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr.K.B.Yadavendra Reddy, P. Mohini, S.Iqbal, THE EFFECT OF ANTITUBERCULAR TREATMENT ON LIVER IN FRESHLY DIAGNOSED PULMONARY TUBERCULOSIS PATIENTS RECEIVING DOTS THERAPY, INDIAN JOURNAL OF APPLIED RESEARCH : Volume‾7 | Issue‾5 | May‾2017

Number of Downloads : 527

References :