THE EFFECT OF INTRAVENOUS LIGNOCAINE ON THE SEVOFLURANE REQUIREMENTS AS MONITORED BY THE BISPECTRAL INDEX

Dr. M.P Santhanakannan; Dr. Aishwarya .R

Volume : VII, Issue : IX, September - 2017

THE EFFECT OF INTRAVENOUS LIGNOCAINE ON THE SEVOFLURANE REQUIREMENTS AS MONITORED BY THE BISPECTRAL INDEX

Dr. M. P Santhanakannan, Dr. Aishwarya . R

Abstract :

INTRODUCTION: Systemic administration of lidocaine significantly decreased propofol requirements when compared to patients receiving placebo. Several studies conducted have proved that systemic local anesthetics reduced minimum alveolar concentration (MAC) of inhalational anesthetics. AIM –This is to know the effect of intravenous administration of lidocaine on the minimum alveolar concentration of sevoflurane required to keep BIS between 40 and 60 during maintenance of anesthesia in humans. METHODOLOGY– Sixty ASA I–II adults planned to undergo laparoscopic procedures expected to last <2 h under general anesthesia were randomly assigned to 2 groups. After standardized induction of general anesthesia, patients were given IV lidocaine bolus (1.5 mg kg_1) followed by 2 mg kg_1 h_1 infusion (group L, n=30) or equal volumes of saline (group S, n= 30). Primary outcome of the study was sevoflurane dial percent at bispectral index (BIS) values of 40–60. And calculated sevoflurane used. Secondary outcomes included doses of opioids, BIS values, intra operative hemodynamics. RESULTS–The mean sevoflurane concentration in group L was 1.19 with a P value of <0.001. and for the mean duration of 85, the sevoflurane required is 19.9ml compared to the group s with mean of 26.11ml with a significant p value. The sevoflurane requirement is reduced by 24%. The secondary outcome of fentanyl requirement in the intraoperative period was also significantly reduced. The lignocaine infusion proved to be the more hemodynamic stability and there was less stress response to intubation in lignocaine group