THE EFFECT OF TRANEXAMIC ACID ON PERIOPERATIVE BLOOD LOSS AND POSTOPERATIVE BLOOD TRANSFUSION REQUIREMENT IN TOTAL KNEE REPLACEMENT

Volume : VII, Issue : VII, July - 2017

Dr Sujana Reddy, Dr Sravanthi, Dr Anusha

Aim Of The Study– To assess the effect of TRANEXAMIC acid on

(1) peri operative blood loss

(2)postoperative blood transfusion requirements

in patients undergoing TKR surgeries when compared with control group.

Materials & Methods– A randomized single blind clinical trial conducted on 60 patients.

Study design was approved by hospital ethical committee and all patients have

consent for the surgery.

The sample size was calculated depending on the previous study 33 and the

case load in the hospital with a power of 80% to detect a difference at the 95%

confidence interval . Considering A Type I error ( α) of 5% and Type II error

( β ) of 20% Power of the study, the sample size was 60. The patients were

randomised in 1:1 ratio into two groups .Group 1 included 30 patients who

underwent TKR without TA while group 2 included 30 patients who underwent

TKR with TA . Group 2 received tranexamic acid 10 mg/kg, just before

cementation followed by 2 similar doses 3 and 6 hours later, this group is the study

group. The group 1 did not receive any treatment for prevention of blood loss

and is the control group.

Conclusions–– To conclude – the effect of TRANEXAMIC acid on

(1) peri operative blood loss is clinically insignificant

(2)postoperative blood transfusion requirements is clinically and statistically significant