Volume : X, Issue : II, February - 2020

The Effect of Vitamin D Supplementation With Sertraline In Patients of Major Depressive Disorder: A 12 Weeks Prospective Interventional Study

Dr. Anupam Sharma, Dr. Vipin Kumar

Abstract :

Depression is a major public health problem and associated with significant disability, mortality and healthcare costs. Vitamin D is a unique neurosteroid hormone that may have an important role in the development of depression. A 12 weeks short term prospective, randomized, interventional, open label clinical study was conducted to evaluate the therapeutic effects of vitamin D as adjunctive therapy to sertraline in patients with major depressive disorder. A total of 60 patients comprised of sample size and by simple randomization they were divided into two groups (groupA=30 & group B=30). Group A (n=30) patients were given sertraline 50mg/daily orally along with vit. D 60000 IU weekly orally for 3months. While group B (n=30) patients received only sertraline 50mg/daily. Depression severity was assessed at 3, 6, 9 and 12 weeks using the 24–item Hamilton Depression Rating Scale. We find that vitamin D is safe and effective as an adjunc¬tive treatment to Sertraline in major depressive disorder

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Article: Download PDF    DOI : 10.36106/ijar  

Cite This Article:

THE EFFECT OF VITAMIN D SUPPLEMENTATION WITH SERTRALINE IN PATIENTS OF MAJOR DEPRESSIVE DISORDER: A 12 WEEKS PROSPECTIVE INTERVENTIONAL STUDY, Dr. Anupam Sharma, Dr. Vipin Kumar INDIAN JOURNAL OF APPLIED RESEARCH : Volume-10 | Issue-2 | February-2020

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