The Effects of The Administration of Quercetin,  Lycium Barbarum Extract and Chitosan on Oxidative  Stress Induced by Exposing Rats to Hypobaric  Hypoxia

Anca DUMITROVICI; Adriana MURESAN; Ramona SIMEDREA; Irina Camelia CHIS

Volume : IV, Issue : II, February - 2014

The Effects of The Administration of Quercetin, Lycium Barbarum Extract and Chitosan on Oxidative Stress Induced by Exposing Rats to Hypobaric Hypoxia

Anca Dumitrovici, Adriana Muresan, Ramona Simedrea, Irina Camelia Chis

Abstract :

Purpose. Acute and chronic hypobaric hypoxia (HH) exposure is considered a physiological oxidative stress that induces the modification of pro-oxidants/antioxidants balance in the entire organism. The aim of this study is to evaluate the protective effects of the natural antioxidants (Quercetin, Lycium barbarum and Chitosan) administration in animals exposed to HH. Study design. 90 Wistar rats were randomly assigned into nine groups and were exposed to HH for one day or 14 days or kept in normobaric normoxia. Some of the rats were treated with natural antioxidants. The serum levels of the free radicals (malondialdehyde and carbonylated proteins) and the antioxidant status (superoxide dismutase, catalase and reduced glutathione) in the blood were measured. Results. The results show an increase oxidative stress after exposure of HH and natural antioxidants supplementation significantly (P<0.05) attenuated the oxidative stress in the blood of the rats. This study suggests that treatment with natural antioxidants can be beneficial in attenuating the oxidative stress associated with exposure of HH.