THE FTO GENE POLYMORPHISM (rs9939609) AS PREDICTOR FOR HYPERTENSION IN IRAQI TYPE 2 DIABETIC PATIENTS

QASIM MOHAMMED TAHER; MAHDI MOHAMMED RIDHA

Volume : VI, Issue : VI, June - 2016

THE FTO GENE POLYMORPHISM (rs9939609) AS PREDICTOR FOR HYPERTENSION IN IRAQI TYPE 2 DIABETIC PATIENTS

Qasim Mohammed Taher, Mahdi Mohammed Ridha

Abstract :

 Background : Type 2 diabetes mellitus (T2DM) and hypertension are major health problems worldwide, associated with increased prevalence of obesity and excess morbidity and mortality. FTO gene is primarily expressed in the hypothalamus and encodes a 2– oxoglutarate–dependent nucleic acid demethylase Method : A case–control study conducted to find the association between SNP rs9939609 in T2DM with and without hypertension in AL–Najaf Governorate, Iraq. The study included 188 T2DM patients with hypertension randomly selected based on World Health Organization (WHO) guideline AND 148 T2DM patients without hypertension as a control group. DNA was extracted from blood and genotyped by PCR–RFLP by using (ScaI) enzyme. Multinominal logistic regression was applied to compare the proportions of genotypes and alleles. The odds ratio for risk of developing hypertension in T2DM was calculated with and without adjustment for age, sex and BMI. Results : FTO gene rs9939609 polymorphism (heterozygous AT, and homozygous AA genotype was exhibited to have a protective role against the development of hypertension in type 2 diabetic patients, after the adjustment for age, sex and BMI. Conclusion : The SNP of FTO rs9939609 gene have a protective role against the occurrence of hypertension in type 2 diabetic patients in Al–Najaf Governorate, Iraq, and changes of the serum lipid concentration as well as Rseistin levels may be taken place independent on the types of the investigated genotypes. BMI is seemed to be independent on the genotype of the investigated gene (FTO rs9939609).