Volume : V, Issue : XI, November - 2015

The Impact of Apo E Genetic Polymorphism on Carotid intimal�medial Thickness in Diabetic Elderly

Dr. Motassem Salah Amer, Dr. Laila Ahmad Abdurrahman, Dr. Randa Reda Mabrouk, Dr. Manar Mostafa Adel, Dr. Doaa Mohamed Abdel Aziz, Dr. Sherine Mohamed Ibrahim Sharara, Rasha Ahmed Mohammed Ali

Abstract :

<p> Aim: to investigate associations between ApoE polymorphisms and CIMT in elderly diabetics Methods: This was a case– control study, ApoE genotyping was tested, total cholesterol, HDL–C, LDL–C, TG and bilateral carotid ultrasound was done in ninety elderly subjects who were divided into thirty elderly diabetic subjects with cardiovascular complications (group A), thirty elderly diabetic subjects without cardiovascular complications (group B) and thirty elderly subjects without DM (group C). Results: The carotid plaques were significantly more frequent among those have E4 alleles in diabetic patients with cardiovascular complications while no significant association between different ApoE alleles and mean CIMT. Conclusions: ApoE gene polymorphisms are significantly associated with increased risk of carotid plaque formation not intimal media thickness (IMT).</p>

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr. Motassem Salah Amer, Dr. Laila Ahmad Abdurrahman, Dr. Randa Reda Mabrouk, Dr. Manar Mostafa Adel, Dr. Doaa Mohamed Abdel Aziz, Dr. Sherine Mohamed Ibrahim Sharara, Rasha Ahmed Mohammed Ali / The Impact of Apo E Genetic Polymorphism on Carotid intimal�medial Thickness in Diabetic Elderly / Indian Journal of Applied Research, Vol.5, Issue : 11 November 2015

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