Volume : IV, Issue : IV, April - 2014

The Number of HOFBAUER Cells Increases in Preeclamptic Placenta:an Immunohistochemical Study

G. Priya, J. Radhika Krishnan, S. Sundarapandian

Abstract :

 OBJECTIVE:Hofbauer cells are fetal macrophages residing in the stroma of the chorionic villi of the human placenta.These cells are thought to function in many processes, but the possible role of hofbauer cells in placenta is unclear.Hofbauer cells are located close to trophoblast cells and fetal capillaries, changes in distribution or phenotype of these cells  may be involved in the pathogenesis of preeclampsia. The aim of this study was to quantify the number of hofbauer cells in preeclamptic placental tissue compared with normal.

MATERIALS AND METHODS:Placentas of  control(n=50) and preeclampsia(n=50) pregnancies were sequentially immunohistochemically stained for CD 68( macrophage marker). Results were evaluated in a semi–quantitative method.

RESULTS:CD68 cells increased significantly in preeclamptic placentas compared with control(6.9±1.07 and 3.8±0.91 respectively) .

CONCLUSION:We hypothesized that the increased number of hofbauer cells in preeclamptic placenta may be involved in the pathogenesis of preeclampsia.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

G.PRIYA, J.RADHIKA KRISHNAN, S.SUNDARAPANDIAN The Number of HOFBAUER Cells Increases in Preeclamptic Placenta:an Immunohistochemical Study Indian Journal of Applied Research, Vol.IV, Issue. IV

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