The Risk of Colorectal Adenomas in Patients with Nonalcoholic Fatty Liver Disease (Nafld). A Case–Control, Prospective Study

Tantau Alina; Tantau Marcel; Szanto Paula; Negrean Vasile; Visovan Ioana; Sampelean Dorel

Volume : IV, Issue : IV, April - 2014

The Risk of Colorectal Adenomas in Patients with Nonalcoholic Fatty Liver Disease (Nafld). A Case–Control, Prospective Study

Tantau Alina, Tantau Marcel, Szanto Paula, Negrean Vasile, Visovan Ioana, Sampelean Dorel

Abstract :

Few studies have evaluated the prevalence of colonic adenomas and carcinomas on patients with NAFLD. We included in the study 100 patients with or without NAFLD who underwent panchromoendoscopy. NAFLD with or without nonalcoholic steatohepatitis (NASH) was diagnosed by liver biopsy or by abdominal ultrasounds followed by laboratory tests to eliminate the other causes of steatosis. We detected 12 colonic advanced neoplasms and 52 adenomas. No difference in the detection rate of adenomas (32% vs. 22%; p=0.260), but there was difference in the prevalence of advanced colonic neoplasms (20% vs. 4%; p<0.014) between groups. Multivariate regression analysis demonstrated an independent risk of colorectal adenomas with NASH after adjustment, according to demographic and metabolic factors (OR= 9.52; p=0.010). The prevalence of adenomas and carcinomas is higher in patients with NAFLD than non–NAFLD patients. NASH is an independent factor that is associated with the presence of colorectal adenomas