The Role of Atrial Natriuretic Peptide T Left  Ventricular Function and Electrolyte Homeostasis in  Congestive Heart Failure Patients

Fadhila Shahwan Al-Doski; Abdul-Aziz Ahmed Aziz; Jasim M. T. Al-Hayali

Volume : IV, Issue : II, February - 2014

The Role of Atrial Natriuretic Peptide T Left Ventricular Function and Electrolyte Homeostasis in Congestive Heart Failure Patients

Fadhila Shahwan Al Doski, Abdul Aziz Ahmed Aziz, Jasim M. T. Al Hayali

Abstract :

Atrial natriuretic peptides(ANP) attract great attention in the last years. This interest is due to the fact that natriuretic peptides plays an important role on body fluids and electrolytes balance and on blood pressure homeostasis under normal physiological conditions as well as in a variety of cardiovascular diseases (CVDs),especially congestive heart failure.

The present study was conducted on 100 subjects(50) patients with congestive heart failure (CHF) who admitted to the Coronary Care Unit, Medical wards and Echocardiography Unit at Ibn-Sena teaching hospital, Mosul, Iraq, from 1^st October 2003 to 30^th September 2004,and also (50) apparently healthy volunteers as control group included in this study.

The biochemical parameters were measured in plasma which include the concentrations of sodium (P_Na), potassium (P_K), creatinine (P_Cr), urea (P_Ur), osmolality (P_Osm), and ANP. The concentration of other parameters were also measured in urine including sodium (U_Na), potassium (U_K), osmolality (U_Osm) and creatinine (U_Cr). Using plasma and urine values, calculation of creatinine clearance (C_Cr) and fractional excretion of sodium (FE_Na) were done. Echocardiographic assessment of left ventricular ejection fraction (LVEF) was also done.

In conclusion, plasma level of ANP was significantly elevated in patients with CHF and it could be considered as an important diagnostic and prognostic indicators especially in patients with CHF. A considerable degree of disturbance in body fluids and electrolytes balance together with significant reduction in renal function also occur in patients with CHF. The study further accentuates the essential role of ANP in the defense mechanisms against body fluids and electrolytes disorders in different CVDs including congestive heart failure patients.