THE ROLE OF TNF�ALPHA AND IL�6 LEVEL WITH IR IN TYPE�II DIABETES MELLITUS.

Krishan Gopal; Rajiv Nehra; Vikas Kumar Gupta; Sanjeev Kumar singh

Volume : VII, Issue : II, February - 2017

THE ROLE OF TNF�ALPHA AND IL�6 LEVEL WITH IR IN TYPE�II DIABETES MELLITUS.

Krishan Gopal, Rajiv Nehra, Vikas Kumar Gupta, Sanjeev Kumar Singh

Abstract :

Objective : Diabetes mellitus is also known as inflammatory disease because persistent hyperglycemia may stimulate the innate immune system in body. This study is mainly focusing on the possible role of proinflammatory markers TNF–α and interleukin–6 along with insulin resistance in type –2 diabetic subjects.

Material & Methods : The study was conducted in 200 human subjects out of whom 100 were normal healthy individuals (group I) and 100 were type 2 diabetic subjects with complication (group II).

RESULTS : Showing the comparative changes of immunological and insulin resistance (HOMA–IR) parameters in group I healthy male and female subjects and group II diabetic male and female subjects. TNF–α, IL–6,(HOMA–IR) were highly significant at (P<0.001).

CONLUSION: Outcome of this study showed that IL–6 and TNF–α plays an important role in insulin resistance. The adipokines produced by adipocytes or by adipose tissue infiltrating macrophages, are able to induce a low grade inflammation state that could play a central role in obesity and type–2 diabetes related insulin resistance.