Volume : VII, Issue : II, February - 2017

The study of drug interaction of Glipizide with Dapsone on blood glucose level in diabetic mice

Dr. Devendra Singh Doneriya, Dr. Savita Vyas

Abstract :

 Infections are common co–morbidity found in many patients suffering from diabetis mellitus and dapsone may be prescribed along with the anti–diabetic agent. Therefore, present work was planned to evaluate drug–drug interaction between dapsone with glipizide. The study also included evaluation of per se effects of each drug as well as their combinations in alloxan induced diabetic mice. 

In this work, we evaluated drug interaction of dapsone (50 mg/kg p.o.), glipizide (2.5 mg/kg p.o.) and combination of glipizide with dapsone (2.5 + 50 mg/kg, p.o.). The results showed that glipizide reduced blood glucose levels at 2, 3 and 5 hrs period and the difference were statistically significant at 3 and 5 hrs in comparison to control group (p< 0.05). The dapsone per se showed slight decrease in blood glucose levels which was comparable to the control group (p>0.05). However, statistically significant difference in comparison to glipizide group was observed at 3 and 5 hrs (p<0.05) as the blood glucose reduction was significantly less in comparison to that of the glipizide group. It indicated no acute effect of dapsone on blood glucose level. However, the combination group (G+D) produces significant decrease in blood glucose levels as compared to control group at 3 and 5 hours and results were comparable to that of the glipizide groups. The results showed no significant acute variation on blood glucose by dapsone when given in combination with glipizide. So, the finding of DI of glipizide with dapsone suggest that acute administration of anti leprosy drug dapsone per se did not affect blood glucose level as well as if it is used as combination with anti diabetic drug glipizide.

 

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr. Devendra singh Doneriya, Dr. Savita Vyas, The study of drug interaction of Glipizide with Dapsone on blood glucose level in diabetic mice, INDIAN JOURNAL OF APPLIED RESEARCH : Volume‾7 | Issue‾2 | February‾2017

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