The Validity Of Rapid Intraoperative And Preoperative Crush Smear Cytology In Detection Of Malignancies Of The Gastro Intestinal Tract, Gall Bladder And The Breast

Amulyajit Kaur; Dr. Neeraj Kaur; Akanxa Bhatti; Dr. Kanwaljeet Singh Hura

Volume : VII, Issue : VII, July - 2017

The Validity Of Rapid Intraoperative And Preoperative Crush Smear Cytology In Detection Of Malignancies Of The Gastro Intestinal Tract, Gall Bladder And The Breast

Amulyajit Kaur, Dr. Neeraj Kaur, Akanxa Bhatti, Dr. Kanwaljeet Singh Hura

Abstract :

Aim of study: To study the reliability of rapid crush smear pre–operative (pre–op) and intra–operative (intra–op) cytological diagnosis in detection of malignancies of gastrointestinal tract (GIT), east and gall bladder lesions. An early intra–op and pre–op cytological diagnosis is an important diagnostic aid and often considered comparable to histopathological examination (HPE).

Material & Methods: Crush smear preparations of biopsies obtained from 92 patients for an early pre–op and rapid intra–op diagnosis were studied. The diagnosis provided was compared with histopathology on same tissue done later. Endoscopic biopsies from 58 suspicious gastrointestinal (GI) lesions were labeled as pre operative biopsies. In addition, 34 consecutive ‘suspicious for malignancy intra operative biopsies’ (5 from the GI tract, 11 and 18 were from east and gall bladder lesions respectively) were subjected to a rapid cytological diagnosis. Reliability of the cytodiagnosis in terms of specificity, sensitivity and predictive values was studied by subjecting the same biopsies to the gold standard histopathological examination.

Results: The sensitivity, specificity, positive and negative predictive values in all the cases altogether were 94.2%, 100%, 100% and 87% respectively. False negative results were obtained for a case of GI biopsy with Non Hodgkin’s lymphoma, lesions with predominant necrosis and well differentiated adenocarcinomas. There were no false positives results.

Conclusion: This study emphasizes rapid pre op and intra op cytomorphodiagnosis of squash preparations as a quick, simple, efficacious, inexpensive and a useful adjunct to conventional, time consuming, biopsy reporting of malignancies of the GI tract, east, and gall bladder.