Volume : V, Issue : VI, June - 2015

Therapeutic and Chemopreventive Effects of Curcumin in Human Colorectal Cancer Cells in Vitro

Entissar S. Al 45 Suhaibani

Abstract :

 Chemoprevention is a promising anti–cancer approach with reduced secondary effects in comparison to classical chemotherapy. Curcumin, one of the most studied chemopreventive agents, is a natural compound extracted from Curcuma longa L. that allows suppression, retardation or inversion of carcinogenesis. The anticancer effect of curcumin, via apoptosis induction resulting from mitochondrial dysfunction, was assessed in colorectal cancer (Caco–2) cells in vitro with an IC50 of 260μg/mL. Treatment of Caco–2 cells with curcumin encouraged apoptosis and antiproliferative effect with cell death–transducing signals by a down–regulation of Bcl–2 and up–regulation of caspases–3 expression were also observed in the treated cells. Additionally, a typical characteristics of apoptosis including DNA fragmentation which is caspase–3 dependent and cytological alterations was observed. Future study will may deal with further investigations of curcumin possible usages as a new alternative or complementary chemotherapeutic agent for human cancer types specially colorectal cancer type.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Entissar S. Al-Suhaibani Therapeutic and Chemopreventive Effects of Curcumin in Human Colorectal Cancer Cells in Vitro Indian Journal of Applied Research, Vol.5, Issue : 6 June 2015

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