Thrombocytopenia in Dengue Fever and the role of platelet transfusion

Dr Deepu David; Dr Suma Mary Thampi; Dr Murugan TP; Dr Subhankar Mitra; Dr KPP Abhilash

Volume : VI, Issue : IV, April - 2016

Thrombocytopenia in Dengue Fever and the role of platelet transfusion

Dr Deepu David, Dr Suma Mary Thampi, Dr Murugan Tp, Dr Subhankar Mitra, Dr Kpp Abhilash

Abstract :

Background: Dengue fever (DF) is an upcoming public health issue. Prophylactic blood product transfusions are commonly practiced though not recommended. This study reviews the clinical profile of patients with DF, details of resuscitation and blood product transfusion in our hospital. Methods: A prospective observational study enrolling patients presenting with clinical suspicion of DF. Detailed history, physical findings, laboratory investigations and treatment modalities were documented. Results: Thrombocytopenia was observed in 86 % of patients. Severe thrombocytopenia at admission was seen in 22 % of patients. Only 7.2% of the patients required platelet transfusions. Severe thrombocytopenia had higher mean hemoglobin and total WBC counts, higher rate of overt bleeding, DHF as well as and mortality. No significant association was noticed with age, duration of failure and occurrence of DSS. Conclusion: Early recognition of dengue and prognosticating severity of illness, rather than prophylactic transfusion will ensure good clinical outcomes.