Timing principle and rapid sequence intubation: A preliminary study

Azhar Mubarak K; Pramod M Velankar; Mary Samuel; Deepasri Chowdhury

Volume : VI, Issue : VIII, August - 2016

Timing principle and rapid sequence intubation: A preliminary study

Azhar Mubarak K, Pramod M Velankar, Mary Samuel, Deepasri Chowdhury

Abstract :

Background and objectives: Rapid sequence induction–intubation(RSI) is very important in general anesthesia(GA) for safety of the patients. The Timing principle uses a single intravenous (IV) bolus dose of non–depolarizing muscle relaxant followed by induction drug at the onset of clinical weakness. This method can be used for RSI. Methodology: 40 patients were equally divided into two groups, group S and group V. Group S received succinylcholine 1.5mgkg–1 and group V vecuronium 0.1 mgkg–1. Intubating conditions were assessed in both the groups according to a grading scale and hemodynamic response to intubation was compared at 1, 3 and 5 min after intubation. Results: Using timing principle intubating conditions with vecuronium were excellent in 75% and good in 25% patients. There was statistically significant increase in pulse rate and blood pressure at one minute after intubation but these parameters rapidly decreased at 3 and 5 minute after intubation. These observations were comparable to those seen with succinylcholine.