TO DETERMINE CORRELATION OF OBSTRUCTIVE SLEEP APNEA HYPOPNEA SYNDROME WITH GLUCOSE INTOLERANCE AND DYSLIPIDEMIA IN GENERAL POPULATION

Dr. Kshitiz Sharan; Dr. Nishant Srivastava; Dr.Lokendra Dave; Dr.T.N.Dubey

Volume : VIII, Issue : VII, July - 2018

TO DETERMINE CORRELATION OF OBSTRUCTIVE SLEEP APNEA HYPOPNEA SYNDROME WITH GLUCOSE INTOLERANCE AND DYSLIPIDEMIA IN GENERAL POPULATION

Dr. Kshitiz Sharan, Dr. Nishant Srivastava, Dr. Lokendra Dave, Dr. T. N. Dubey

Abstract :

Introduction:Obstructive sleep apnea and hypopnea syndrome is associated with many metabolic derangements.Better understanding of these relationships will help in improved management and prevention of cardiovascular complication of this disease.Aim and Objectives:To determine correlation of Obstructive sleep apnea hypopnea syndrome with glucose intolerance, and dyslipidemia.

Material and methods: Observational study of 100 participants who were healthy attendants of patients presenting to Hamidia hospital from 1^stDecember 2015 to 31^st May 2017 and underwent full night in lab polysomnography and blood investigations.All participants were aged between 13 and 85 years. Pregnant ladies ,hypothyroid participants ,alcoholics and persons with enlarged tonsils and adenoids were excluded.

Results:Mean fasting blood sugar was 87.52 mg/dl,103.5 mg/dl,107.13 mg/dl,114.12 mg/dl and mean postprandial blood sugar was 125.28 mg/dl,142.43 mg/dl,152.03 mg/dl and 165.16 mg/dl in normal, mild, moderate and severe AHI groups respectively.17(>70%) persons with severe AHI had serum cholesterol level > 240 where as only 1 person with normal AHI had serum cholesterol > 240.The mean serum cholesterol in mild, moderate, severe AHI Group was 166.76 mg/dl,225.09 mg/dl,233.91 mg/dl and 257.45 mg/dl respectively.A statistically significant relation between increasing severity of hypercholesterolemia and obstructive sleep apnea and hypopnea syndrome was found. Increasing AHI was significantly related with increasing serum triglyceride. The mean serum triglyceride in mild, moderate, severe AHI group was 147.96 mg/dl,148.21 mg/dl,157. 85 mg/dl.Out of 10 normal AHI male participants only2 had serum HDL level less than 40 mg/dl and for severe AHI the value was 12 out of 15. The p value for males was 0.0015 and for females <0.5484 suggesting correlation of increasing AHI and decreasing serum HDL only in males.Conclusion:Increasing severity of obstructive sleep apnea hypopnea syndrome was associated withimpaired glucose tolerance ,hypertriglyceridemia and hypercholesterolemia.Obstructive sleep apnea hypopnea syndrome was associated with decreasing HDL levels only in males.