To evaluate the efficacy of a low dose of ketamine in attenuating haemodynamic stress response induced by pneumoperitoneum in laproscopic cholecystectomy under general anaesthesia–A Prospective Study

Dr. Sumit Kumar; Dr. Jatin Patel; Dr. Pardumanjit S Dhaliwal; Dr. Akhilesh Chhaya; Dr; Dinesh Chauhan

Volume : VIII, Issue : I, January - 2018

To evaluate the efficacy of a low dose of ketamine in attenuating haemodynamic stress response induced by pneumoperitoneum in laproscopic cholecystectomy under general anaesthesia–A Prospective Study

Dr. Sumit Kumar, Dr. Jatin Patel, Dr. Pardumanjit S Dhaliwal, Dr. Akhilesh Chhaya, Dr, Dinesh Chauhan

Abstract :

Background

Pneumoperitoneum affects homeostasis and leads to alterations in cardiovascular and pulmonary stress response during laproscopy. Various pharmacologic interventions have been tried to attenuate the response. N–methyl d–aspartate (NMDA) receptor antagonists like MgSO4 have received great attention. We conducted this study using low dose of ketamine in attenuating pressor response.

Method

Patients who underwent laparoscopic cholecystectomy divided in group K (ketamine0.5 mg/kg)and group N(Normal saline). After induction of general anaesthesia but ten minutes before creation of pneumoperitoneum, the (group K) received ketamine 0.5 mg/kg diluted in normal saline intravenously where as group N received same amount of Normal saline. Haemodynamic parameters recorded and results observed.

Results

Heart Rate,Systolic Blood Pressure, Diastolic Blood Pressure, Mean Arterial Pressure were significantly attenuated in group K(p<0.05) as compared to group N

Conclusion

ketamine attenuates hemodynamic response in pneumoperitonium in laparoscopic cholecystectomy without changes in ETCO2.