IJAR - Indian Journal of Applied Research

Dr P. Beck; Dr Virendra K.Kurrey; Dr Prafull Dawale

Volume : V, Issue : X, October - 2015

To study lipid profile and its correlation with serum albumin level in Nephrotic syndrome in children

Dr P. Beck, Dr Virendra K. Kurrey, Dr Prafull Dawale

Abstract :

Introduction – Hyperlipidemia is familiar feature of Nephrotic syndrome and usually observed during the active phase of the disease and disappears with resolution of proteinuria. Persistence and severity of lipid changes in serum correlates well with the duration and frequency of the relapses, hence close monitoring of lipid levels is necessary to anticipate complication. Material and methods – Prospective observational cohort study, all children in the age group of 0–12 years with nephrotic syndrome at onset and remission /relapse were included in study and were undergone for serum lipid and albumin estimation. Obtained data were analyzed statistically. Result – The total cholesterol, LDL,TG levels were significantly high as compared to control. There was significant correlation present between albumin and HDL. Serum cholesterol level in relapse case was significantly higher than mean cholesterol in first episode nephrotic syndrome. Conclusion – Monitoring of lipid levels during the remission of the nephritic syndrome especially in those with relapses, is necessary to anticipate complication. No definite correlation can be established between the degree of hypoalbuminemia and rise of lipids.