TO STUDY THE CO�RELATION OF TUBERCULIN  TEST (MANTOUX TEST) WITH THE IMMUNO SUPPRESSION (CD4 LYMPHOCYTE COUNT) IN HIV/TB CO�INFECTION.

DR.R.K.RATHOD; DR.B.B.BHADKE; DR.A.B.LUNIYA; DR.D.G.DESHMUKH; DR.A.SURJUSHE

Volume : VI, Issue : V, May - 2016

TO STUDY THE CO�RELATION OF TUBERCULIN TEST (MANTOUX TEST) WITH THE IMMUNO SUPPRESSION (CD4 LYMPHOCYTE COUNT) IN HIV/TB CO�INFECTION.

Dr. R. K. Rathod, Dr. B. B. Bhadke, Dr. A. B. Luniya, Dr. D. G. Deshmukh, Dr. A. Surjushe

Abstract :

AIMS AND OBJECTIVE : 1.) To study the co–relation between Mantoux tests with CD–4+T cell count in HIV/TB co infected patient.2.) To estimate the cut of level of CD4 counts below which anergy is observed. MATERIAL AND METHODS:– This is a prospective, observational study conducted in the Department of Pulmonary Medicine, Shri Vasantrao Naik Govt.Medical College,Yavatamal , Maharashtra (India) over a period of 2 years from January 2014 to April 2016 . Total 210 HIV proven naive patients with clinical suspicion of Tuberculosis with normal or abnormal chest X–ray were enrolled. Patients already on anti–tubercular and anti–retroviral treatment were excluded. Evaluation of each patient was done which included history, clinical examination, sputum examination, and Tuberculin test, radiological investigational and CD4 T Lymphocytes. RESULTS:– Out of 210 patients subjected to Mantoux test 60 (28.6%) patients were found to be positive and 150 (71.4%) patients were found to be negative. Anergy (0 mm) was noted in 75 (35.7%) among these 74 (98.66%) patients having CD4 T Lymphocytes count < 200 / cumm , only 1 patient CD4 T Lymphocytes count < 200/ cumm and paients with CD4 T Lymphocytes < 50 were 44( 58.66 %). Out of 60 Mantoux positive patients 30, 28 and 2 had induration of 6–10 mm, 11–20mm and >20mm respectively. Among these 54 were having CD4 T Lymphocytes count < 200/cu.mm, while 6 patients had CD4 T Lymphocytes count of > 200/cu.mm. CONCLUSION:– Mantoux test and CD4 count matched correlation was found with the level of immune deficiency and hence we conclude that Mantoux test may be incorporated in the clinical management of AIDS patients.