TO STUDY THE EFFECT OF DEXMEDETOMIDINE ON THE HEMODYNAMIC AND RECOVERY RESPONSES DURING TRACHEAL EXTUBATION

DR. SONALI HASTIR; DR. MARY SAMUEL

Volume : IX, Issue : I, January - 2019

TO STUDY THE EFFECT OF DEXMEDETOMIDINE ON THE HEMODYNAMIC AND RECOVERY RESPONSES DURING TRACHEAL EXTUBATION

Dr. Sonali Hastir, Dr. Mary Samuel

Abstract :

INTRODUCTION:Marked increases in arterial blood pressure and heart rate occur frequently at the time of extubation. These effects are alarming and, may cause detrimental increases in intracranial and intraocular pressure after neurologic and ophthalmic surgery. Dexmedetomidine is a highly selective α–2 adrenoceptor agonist that has sedative, anxiolytic ,hypnotic, analgesic and sympatholytic properties , shows a high ratio of specificity for the α2 receptor (α2/α1 1600:1) making it a complete α2 agonist and has a short half–life of 2–3 hours. MATERIALS AND METHODS:The study was conducted on sixty patients (thirty in each group) undergoing surgery under general anaesthesia Patients in group A recieved Intravenous infusion of dexmedetomidine 0.5 mcg/kg body weight in 100ml normal saline.Patients in group B recieved Intravenous placebo with 100 ml normal saline 15 minutes prior to extubation.RESULTS: dexmedetomidine as given in group A before extubation attenuates the hemodynamic response , enables smooth extubation and provides adequate sedation ,these results were statistically significant (p<0.005) Incidence of adycardia and hypotension was seen in group A but was statistically insignificant.