TO STUDY THE MAGNITUDE OF CANDIDEMIA IN INTENSIVE CARE UNIT PATIENTS IN S.M.S. MEDICAL COLLEGE AND HOSPITALS, JAIPUR

Dr.Kanhaiya Lal Verma; Dr.Aruna Vyas; Dr.Rajani Sharma; Dr.R.K.Maheshwari

Volume : VI, Issue : V, May - 2016

TO STUDY THE MAGNITUDE OF CANDIDEMIA IN INTENSIVE CARE UNIT PATIENTS IN S.M.S. MEDICAL COLLEGE AND HOSPITALS, JAIPUR

Dr. Kanhaiya Lal Verma, Dr. Aruna Vyas, Dr. Rajani Sharma, Dr. R. K. Maheshwari

Abstract :

Background: The incidence and prevalence of candidemia is on a rise worldwide. Non–albicans Candida species has emerged as major cause of candidemia globally. Incidence of antifungal resistance is rising to especially in ICU. Objectives: To study the magnitude of candidemia in ICU antifungal susceptibility pattern and various risk factors associated with candidemia. Materials and Methods: All Candida isolates from blood stream infection of ICU Patients (555) were included in the study period (April 2015–June 2015). The isolates were identified with automated Vitek–2 compact system of Biomarix,Germoney,using the YST ID cards and their antifungal susceptibility was performed using AST YS 06 Cards . Results: A total of 24 (4.32%) Candida isolates were found among 555 ICU patients Candida tropicalis (33.33%) was the most common isolate followed by Candida krusei, Candida albicans, Candida parapsilosis , Candida pelliculosa, Candida pseudotropicalis and Candida guilliermondii. Among the 24 Candida isolates , resistance to the fluconazole was 37.5%, to voriconazole 0%, to amphitericin B 12.5%, flucytocin 25%, caspofungin 8.33% and micafungin 8.33%. The risk factors commonly associated with candidemia patients were long term antibiotic therapy (54.17%), central venous catheters (37.15%), urinary catheters (16.67%), ventilator (16.67%) and low birth weight (16.67%). Conclusion: Candidemia is emerging as a significant problem in hospitalized patients, especially in ICU setups. Nonalbicans Candida species are the major cause of candidemia as found in our study .