To study the role of Serum Adenosine Deaminase levels in patients with carcinoma breast.

Dr Mohd Javed Banday; Dr Kulbir Singh Jat

Volume : VIII, Issue : IV, April - 2018

To study the role of Serum Adenosine Deaminase levels in patients with carcinoma breast.

Dr Mohd Javed Banday, Dr Kulbir Singh Jat

Abstract :

Adenosine deaminase was found to be the better probable parameter for the detection of cancer and to assess the development of various stages of cancer whereas 5‘–nucleotidase had only diagnostic significance. Serum alkaline phosphatase levels were important for assessing the spread of cancer at secondary sites. After mastectomy a significant decrease was found in the levels of serum ADA and 5‘–NT whereas no variations were found in case of serum ALP.

Aims and objectives

The potential relationship between adenosine deaminase activity and cancer progression was examined by investigating the activity of total ADA and its isoenzymes in serum and simultaneously in the cancerous tissue of each patient with east cancer.

Material and methods

Twenty five biopsy proved cases of carcinoma east were selected from department of surgery, medical college and hospital .The control group consisted of 25 age matched healthy females. For all the patients detailed history of the present and past illness, family history and personal history was recorded. Detailed clinical examination and routine investigations were carried out for each patient. The study group included all the patients with following exceptions:

a) Patients who have already received treatment for malignancy in any form.

b) Patients who had acute or chronic infection.

After examination and investigations, all the patients were graded into various stages as per Manchester and TNM classification.

Conclusions

Serum ADA activity was significantly higher in patients of carcinoma east as compared to the controls. The procedure thus has a diagnostic value. The increase in serum ADA activity did not bear any direct correlation with the advancing stage of malignancy.