Toxicopathologic effects of Sodium Fluoride on Male‘s reproductive system of rabbits

Miss Zainab I. Ibrahim; Miss Enaam Bader Falih

Volume : VI, Issue : II, February - 2016

Toxicopathologic effects of Sodium Fluoride on Male‘s reproductive system of rabbits

Miss Zainab I. Ibrahim, Miss Enaam Bader Falih

Abstract :

<p>&lt;p&gt;&amp;lt;p&amp;gt;&amp;amp;nbsp;Objectives: recently appeared that NaF had serious problems on the emyonic development due to its cytotoxic effect, so the purpose of the present study to estimate the chronic toxic effects of NaF on the male genital system of wild rabbits. Study: eighteen males of wild rabbits, divided into three groups; 1st group from six males of them were administered only single dose 50 ppm / NaF, 2nd group six males orally administered 50 ppm of NaF /45 days, 3rd group given PBS as negative control group. For histopathological study all animals sacrificed post time of toxicity for cytogenetic and. Results: in testes there was atrophic necrosis and thickening of the basement memanes of seminiferous tubules, edematous fluid and hyalinization, vacuolar degenerative changes in sertoli cells, prostatic hyperplasia in chronic form of toxicity was recorded. Conclusions: long time administration of NaF had severe necrotic changes on testicular tissues and diminished the spermatogenesis.&amp;lt;/p&amp;gt;&lt;/p&gt;</p>