TT3, TT4 and TSH levels during pregnancy in a known Iodine deficient region of upper Assam

Dr. Saurabh Borkotoki; Dr. Uttara Borkotoki; Dr. Reetwik Kumar Dutta; Mr. Rituraj Baruah

Volume : VII, Issue : V, May - 2017

TT3, TT4 and TSH levels during pregnancy in a known Iodine deficient region of upper Assam

Dr. Saurabh Borkotoki, Dr. Uttara Borkotoki, Dr. Reetwik Kumar Dutta, Mr. Rituraj Baruah

Abstract :

Body adapts to the increased demands of Thyroid hormones by increasing activity of the thyroid gland. The present study is carried out in subjects visiting Jorhat Medical College Hospital from three upper Assam districts of Jorhat, Golaghat and Sivsagar in their first trimester of pregnancy with an aim to compare their thyroid hormone status with similar age/sex matched controls hailing from the same districts. Serum total T3 (TT3), total T4 ( TT4) and thyroid stimulating hormone ( TSH) levels evaluated in 301 first trimester pregnant women and 300 non– pregnant controls using Access Immunoassay Systems ( Beckman Coulter) at the clinical biochemistry wing of Central Clinical Laboratory, Jorhat Medical College & Hospital, Jorhat , Assam. Statistical analysis done using SPSS 16.0 version. Highly significant increased results were obtained in pregnancy for TT3 ( 1.5212 µgm/dl ± . 27952 µgm/dl ) and TT4 (11.5142 ngm/ml ± 2.60105 ngm/ml) when compared with the controls – TT3 (1.0926 µgm/dl ± 0.2678 µgm/dl ) and TT4 (8.4423 ngm/ml ± 2.03523 ngm/ml). Thus, the study reaffirms the physiological hyperactive state of the thyroid gland in first trimester of pregnancy.