Volume : VIII, Issue : IX, September - 2018

Ulcerative Colitis with positive proteinase–3 antineutrophil cytoplasmic antibody.

Singh Usha, Shevra Rani, Dr Vk Dixit

Abstract :

Proteinase–3 (PR–3) antineutrophil cytoplasmic antibody (ANCA) is a diagnostic marker for Wegner’s granulomatosis. Presence of PR–3 ANCA is extremely rare in ulcerative colitis (UC). Herein we are reporting 2 cases of Ulcerative Colitis which were positive for PR–3 ANCA. Two male patients aged 35 and 57 years presented with features with features of ulcerative colitis  with  blood  and  mucus in stool. There was no involvement of respiratory tract, nasal mucosa, skin or kidney in either patient. The laboratory examination of one patient was negative for rheumatoid factor and anti dsDNA antibody, but positive for antinuclear antibody (ANA) and PR–3 ANCA. In the second patient, only PR3 ANCA was positive while tests for ANA, anti ds DNA antibody and rheumatoid factor were negative.  Histopathologically  both cases were diagnosed  as Ulcerative Colitis.  Hence we conclude that PR3–ANCA may cause ulcerative colitis

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Singh Usha, Shevra Rani, Dr VK Dixit, Ulcerative Colitis with positive proteinase–3 antineutrophil cytoplasmic antibody., INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-9 | September-2018

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