Volume : IV, Issue : XI, November - 2014

Using Electrochemical Technique to Detect Her2 Antigen

Phuc Le Thi Minh, Phuc Pham Van, Huan Le Quang

Abstract :

Early diagnosis of east cancer is the most effective way to improve the survival rate and increase more chances of patients with east cancer. In this study, to determine HER2 (human epidermal growth factor receptor 2) antigen, an aptasensor was developed by employing self–assembled of HER2–specific single stranded DNA aptamer on 3–mercaptopropionic acid–modified gold nanoparticles electrode. The surface properties of the gold electrode at each modification step were characterized by changing in cyclic voltammetry and square wave voltammetry responses. The decrease in the peak current was correlation with the concentrations of HER2 in the range of 0.35 ng/ml to 35 ng/ml. The aptasensor was successfully developed to detect HER2 antigen. This study could provide a promising and fast method for early detection of east cancer.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Le Thi Minh Phuc, Pham Van Phuc, Le Quang Huan Using Electrochemical Technique to Detect HER2 Antigen Indian Journal of Applied Research, Vol.4, Issue : 11 November 2014

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