Volume : IX, Issue : IV, April - 2019

VALUE OF ECADHERIN EXPRESSION IN PROSTATE CANCER

Dr. V. Nithyananthinie, Dr. G. Leelavathy

Abstract :

E–cadherin, low expression is associated with progression to higher grades of prostate malignancy and in assessing the metastatic spread of prostate cancer. Aim: To study prostatic carcinomas with altered E–cadherin expression and to correlate with Gleason score and PSA levels. Materials and methods: 25 cases of prostate cancer specimens, were selected and paraffin embedded formalin fixed sections in coated slides were subjected for immunohistochemical expression with E–cadherin antibodies by the peroxidase– antiperoxidase method. Memanous positivity for E–cadherin was observed based on the staining pattern, strength of staining and population of stained cells. Results: E–cadherin was negative in 28% cases and 56% cases showed weak positivity, indicating a considerable loss of E–cadherin as the lesions are progressing and suspected extra prostatic extension. Conclusion: To detect extra prostatic extension, without any major symptoms, E–cadherin can be used even in minimal tissue samples and anticipate the progression.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

VALUE OF ECADHERIN EXPRESSION IN PROSTATE CANCER, DR.V.NITHYANANTHINIE, DR.G.LEELAVATHY INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-4 | April-2019

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