Volume : VIII, Issue : I, January - 2018

Vesicular drug targeting in combating cerebral oxidative injury

Ardhendu Kumar Mandal, Aparajita Ghosh, Nirmalendu Das

Abstract :

 

Brain stroke is the main reason for health disability and mortality among aged pupils worldwide. Mitochondrial dysfunction, due to oxidative stress during cereal ischemia–reperfusion, exerts inflammations and damages to the neurones of the ain. Free form of antioxidant is basically inefficient for the treatment of cereal ischemia as blood ain barrier remains in between systemic blood and ain interstitial fluid. Furthermore, the affectivity of antioxidant compounds may be hindered by their poor permeability, low solubility and enhanced rate of efflux from the effected cells. Therefore, different active compounds encapsulated in various vesicles have been investigated in vivo to prevent ain ischemia. Our review, on the methods applied for the preparation, characterization, and efficacy of vesicular active drug compounds –delivery, has demonstrated a promising aspect, especially for nanoencapsulation in the treatment of cereal ischemia against oxidative cell death with higher biological effectiveness and least side effects.

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Ardhendu Kumar Mandal, Aparajita Ghosh, Nirmalendu Das, Vesicular drug targeting in combating cerebral oxidative injury, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-1 | January-2018

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