Volume : IX, Issue : III, March - 2019

VIRAL CARCINOGENESIS: A REVIEW

Dr. Shatakshi Sharma

Abstract :

Certain DNA and RNA viruses that are associated with Tumors have supported cancer research in two major aspects firstly, to discover and access the control pathways of cellular growth along with formulating the current concepts of cancer biology and, second, to discuss the etiology of some cancers occurring in Humans. In many Transforming retroviruses growth control and mitogenic signalling are found to be associated with oncogenes derived from cellular genes. The discovery of tumor suppressors is corresponding to these oncogenes of viral origin that the DNA tumor viruses encode which are found to be essential for viral replication and Host cell transformation. These virus–host complexes stimulate cell cycle progression. This line of thought states that cancer develops by the accumulation of multiple cooperating events. Viruses including hepatitis B & C virus, Epstein–Barr virus, human T–cell leukemia virus type I and Human papilloma viruses are now considered as genuine causative factors of human cancer. It is the infectious nature of viruses resulting in chronic long–standing infections in humans that acts as a distinguishing factor between them from all other cancer etiologies; with the development of cancer being an unfortunate aftereffect of viral replication. Human Viruses usually do not act as definite carcinogens, and these viruses have different roles in cellular transformations further leading to carcinogenesis. It may take years between primary infection and tumorigenesis and in a number of infected cases cancer development might not even occur, although viral carcinogenesis is predominantly seen in immunocompromised individuals. This article is an effort to explain the Theories and mechanism of viral carcinogenesis including the Factors contributing to viral carcinogenesis such as the Viruses associated, viral oncogenes and deregulation of host cell function. The article will also try to put emphasis on Diagnosis of viral induced carcinogenesis

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

VIRAL CARCINOGENESIS: A REVIEW, Dr. Shatakshi Sharma INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-3 | March-2019

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